Etopophos etoposide phosphate is available in an injection into the vein, but a different form of this medication etoposide. Instructions on how you can make a pdf version of this page using the print function on your browser. Ensuing dna damage response involves cell cycle arrest and dna repair, but eventually cell death if repair is unsuccessful. Severe myelosuppression with resulting infection or bleeding may occur with etoposide. The most prominent side effects were myelosuppression and gi toxicity. Etopophos etoposide injection chemotherapy, side effects. The predominant macromolecular effect of etoposide appears to be the induction. Check with your health care professional if any of the following side effects continue or are bothersome or. Etoposide national library of medicine pubmed health. Etoposide is an inhibitor of the enzyme topoisomerase ii, derived from podophyllum peltatum, the mayapple, a perennial herbaceous plant. It may be used before you get a stem cell transplant. Etoposide induces cell death via mitochondrialdependent.
Options to help manage any side effects that do occur are included on the right side of this table. Vepesid etoposide chemotherapy, side effects navigating care. The effect of renal disease on plasma etoposide clearance is not known. Severe myelosuppression with resulting infection or bleeding may occur. Etoposide is also being studied in the treatment of other types of cancer. Other side effects not listed may also occur in some patients.
There is no relationship between the presence or severity of side effects and the effectiveness of the medication. May 21, 2019 our etopophos etoposide phosphate side effects drug center provides a comprehensive view of available drug information on the potential side effects when taking this medication. Etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. If you experience a serious side effect, you or your doctor may send a report to the. This pilot phase i trial studies the side effects and best dose of everolimus and to see how well it works when given together with nelarabine, cyclophosphamide, and etoposide phosphate in treating patients. Etopophos etoposide phosphate, also commonly known as vp16, is a cancer antineoplastic medication used alone or in combination with other chemotherapies to treat cancer of. Call your doctor for medical advice about side effects. Since the growth of normal body cells may also be affected by etoposide, other effects will also occur. Etoposide intravenous route before using mayo clinic. Etoposide is a semisynthetic derivative of podophyllotoxin, a substance extracted from the mandrake root podophyllum peltatum. The most prominent side effects were myelos uppression and gi toxicity. Etoposide intravenous route side effects mayo clinic. Clinical trials using etoposide national cancer institute. Etoposide uses, side effects, substitutes, composition and.
The following side effects are common occurring in greater than 30% for. In 100 people receiving cisplatin, etoposide, cyclophosphamide. Etoposide 20 mgml concentrate for solution for infusion. Etoposide oral vepesid side effects, medical uses, and.
This medication may lower your ability to fight infections. Etoposide, therefore, is cleared by both renal and nonrenal processes, i. Clinical trials using etoposide phosphate national. September 25, 2017 common, some may be serious in 100 people receiving etoposide, more than 20 and up to 100 may have. Also, your health care professional may be able to tell you about ways to prevent or reduce some of these side effects.
Etoposide may increase the risk that you will develop other cancers. Your doctor may need to change the doses of your medications or monitor you carefully for side effects. The use of etoposide requires an experienced clinician knowledgeable in administering chemotherapy. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide, 32. The side effects of etoposide and their severity depend on how much of the drug is given. Possible side effects of etoposide table version date.
Many other medications may also interact with etoposide, so be sure to tell your doctor about all the medications you are taking, even those that do not appear on this list. Jan 19, 2015 intriguingly, in resting cells inhibition of atm activity with ku55933 blocks ddr and apoptosis by preventing puma expression and caspase activation, while the same protocol increases the cytotoxic effects of etoposide on proliferating tumor cells korwek et al. This phase i ii trial studies the side effects and best dose of lenalidomide when given together with rituximabifosfamidecarboplatin etoposide rice and to see how well they work in treating patients. Etoposide is in the topoisomerase inhibitor family of medication. Infection, especially when white blood cell count is low. Apr 19, 2016 the mean renal clearance of etoposide is 7 mlminm 2 to 10 mlminm 2 or about 35% of the total body clearance over a dose range of 80 mgm 2 to 600 mgm 2. Possible side effects of cisplatin, etoposide, cyclophosphamide, vincristine table version date. However, elderly patients are more likely to have unwanted side effects. Low platelet count this can increase your risk of bleeding. Etoposide can cause fetal harm when administered to a pregnant woman. Jan 01, 2017 etoposide belongs to the group of medicines known as antineoplastic agents. Etoposide can lower blood cells that help your body. Myelosuppression, nausea, and vomiting are the most common adverse effects.
It is used to treat small cell lung cancer and other cancers. Molecular mechanisms of etoposide pubmed central pmc. Etoposide side effects, dosage, interactions drugs. This is not a complete list of side effects and others may occur. Cohort studies of the risk for secondary acute myeloid leukaemia aml after. Sixtyeight percent of patients treated with etoposide phosphate pl us cisplatin had neut rophils less than 500mm 3 at some time during treatment as did 88% of those getting etoposide and cisplatin. The exact way that etoposide acts against cancer is not known. Toposar etoposide dose, indications, adverse effects.
It is used with other chemotherapy as firstline treatment. Possible side effects like all medicines, this medicine can cause side effects, although not everybody gets them. The mean renal clearance of etoposide is 7 mlminm 2 to 10 mlminm 2 or about 35% of the total body clearance over a dose range of 80 mgm 2 to 600 mgm 2. If there is further bone marrow toxicity then reduce etoposide dose by a further 20%. Etoposide by mouth national library of medicine pubmed. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online or by phone 18003321088. The following data on adverse reactions are based on both oral and intravenous administration of vepesid etoposide as a single agent, using several different dose schedules for treatment of a wide variety of malignancies. Repeatdose studies in animals have shown a potential to cause adverse effects on reproductive system and the developing fetus. Check with your health care professional if any of the following side effects continue or are bothersome or if you have any questions about. Read more about the prescription drug etoposide injection. Advise males to use effective contraception for 4 months, after the last dose of etopophos. Other severe side effects include allergic reactions and low blood pressure. Nonhaematological toxicity hepatic astalt unitsl etoposide conflicting information exists for reductions with etoposide.
In 100 people receiving cisplatin, etoposide, more than 20 and up to 100 may have. If you experience a serious side effect, you or your doctor may send a report to the food and drug administrations fda medwatch adverse event reporting program online web or by phone 18003321088. The mean renal clearance of etoposide is 7 to 10 mlminm 2 or about 35% of the total body clearance over a dose range of 80 to 600 mgm 2. Important things to remember about the side effects of etoposide. Sep 19, 2019 etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. Interpatient variability bioavailability oral absorption dosedependent. Although not all of these side effects may occur, if they do occur they may need medical attention. If you notice any other effects, check with your healthcare professional. Common etoposide side effects a study from fda data. It is used in patients who have already been treated with surgery, radiation therapy, or other chemotherapy and have not gotten better. Consumer information about the medication etoposide oral vepesid, includes side effects, drug interactions, recommended dosages, and storage information. After treatment with etoposide has ended, normal hair growth should return.
Etopophos etoposide phosphate has been on the market for over 30 years. These drugs can produce toxic side effects that are more likely to occur when used in combination with each other. Drug name mechanism of action and pharmacokinetics indications and status adverse effects dosing administration. Etoposide 20mgml concentrate for solution for infusion etoposide. Combination of cyclophosphamide, etoposide, carboplatin and dexamethasone as a salvage regimen for refractory multiple myeloma patients. They can include low blood cell counts, vomiting, loss of appetite, diarrhea, hair loss, and fever. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main side effects. Pdf cytotoxicity analysis of etoposide and cisplatin on. Etopophos etoposide phosphate for injection is an antineoplastic agent which is available for intravenous infusion as a sterile lyophile in singledose vials containing etoposide phosphate equivalent to 100 mg etoposide. Capitals indicate lifethreatening, underlines indicate most frequent. In this study the effects of hypoxia on the response of the osteosarcoma cell lines 791t, hos and u2os to the clinically relevant cytotoxics cisplatin, doxorubicin and etoposide were evaluated.
If necessary omit etoposide completely before reducing ifosfamide. Etoposide toposar, vepesid, vp16 upmc hillman cancer. Drug information on vepesid etoposide oral includes side effects, uses, drug interactions, dosage, drug pictures, overdose symptoms, and what to avoid. Only select registry of toxic effects of chemical substances rtecs data is presented. Clinically important side effects are in bold, italics allergy. Each of the side effects above was reported in 20% or greater of patients treated with etoposide. If etoposide is to be used as part of a chemotherapy regimen, the physician should weigh the necessity to use the drug against its potential risk and side effects. Oct 12, 2017 the mean renal clearance of etoposide is 7 to 10 mlminm 2 or about 35% of the total body clearance over a dose range of 80 to 600 mgm 2. Talk to your doctor about the risks of taking this medication. Etopophos etoposide phosphate for injection should be administered under the supervision of a qualified physician experienced in the use of cancer chemotherapeutic agents.
Nov 09, 2018 etoposide is a cancer medicine that interferes with the growth and spread of cancer cells in the body. The following information is intended for medical or healthcare professionals only posology and method of administration by intravenous infusion. When these medicines are given together, drugrelated side effects reported in clinical studies give the best estimate of what to expect. Etoposide may also be used for purposes not listed in this medication guide. Etoposide oral capsule drug information, side effects, faqs.
Etoposide investigated as a drug, mutagen, natural product, reproductive effector, and tumorigen. In clinical studies, the most commonly reported carboplatin plus etoposide drug side effects are shown here. Appropriate studies performed to date have not demonstrated geriatricspecific problems that would limit the usefulness of etoposide injection in the elderly. Side effects of etopophos etoposide phosphate, warnings, uses. Etoposide can be administered either as intravenous infusion or in oral form.
Find patient medical information for etoposide intravenous on webmd including its uses, side effects and safety, interactions, pictures, warnings and user ratings. In other words, high doses may produce more severe side effects. Oral etoposide 50 mgm 2 daily for 21 days every 28 days is a reasonable choice, especially for patients with slowgrowing disease who desire an oral agent. Advise females of potential risk to the fetus and to use effective contraception during treatment with etopophos monthsand for 6 after final dose. Call your doctor or get medical help if any of these side effects or any other side effects bother you or do not go away. Tell your doctor right away if you have any serious side effects, including.
Etoposide oral chemotherapy education page 3 side effects of etoposide the common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the left side of this table. It is usually given in combination with other cancer medicines. The most commonly administered drug combination is abbreviated as emaco, which stands for etoposide. The effect of etoposide on fertility in humans is not known. Common etoposide side effects a study from fda data summary. Carboplatin is used to treat ovarian and lung cancer. However, it seems to interfere with the growth of the cancer cells, which are eventually destroyed. Hematotoxicity, nausea and vomiting, alopecia, and a persistent metallic taste are the main side effects of the oral form. Along with its needed effects, etoposide may cause some unwanted effects. Consumer information about the medication etoposide injection toposar, vepesid, includes side effects, drug interactions, recommended dosages, and storage information.
Read more about the prescription drug etoposide oral. Etopophos etoposide phosphate, also commonly known as vp16, is a cancer antineoplastic medication used alone or in combination with other chemotherapies to treat cancer of the lung or testicles. High doses of etoposide can cause significant hypotension and alcohol. Obtain complete blood counts prior to each cycle and more frequently as clinically indicated. Find medication information including related drug classes, side effects, patient statistics and answers to frequently asked questions. Total dosage must be adapted based upon the myelosuppressive effects of combinations with other medicines and or the effects. Effects of other drugs on the pharmacokinetics of etoposide. Hypersensitivity reactions including anaphylaxis may occur. It is best to read this information with our general information about chemotherapy and the type of cancer you have your doctor will talk to you about this treatment and its possible side effects. You may report side effects to the fda at 1800fda1088. Etoposide is used for small cell lung cancer, testicular cancer etc. Side effects of etopophos etoposide phosphate, warnings. Etoposide is cell cycle dependent and phase specific, affecting mainly the s and g 2 phases. The common side effects that have been known to happen in more than 30% of patients taking etoposide are listed in the.
Vepesid etoposide also commonly known as vp16 is a cancer antineoplastic medication used alone or in combination with other chemotherapies to treat cancer of the testicles or. This product contains ethanol which can cause liver changes, central nervous system effects, and birth defects in the developing fetus chronic. Apr 10, 2018 talk to your care provider or dentist before any scheduled procedures. Etoposide side effects, dosage, interactions drugs everyday health search. Options to help manage any side effects that do occur are included on the right side. Toposar should be given only by slow intravenous infusion usually over a 30 to 60minute period since hypotension has been reported as a possible side effect of rapid intravenous injection. These side effects may go away during treatment as your body adjusts to the medicine. In a multidrug regimen, each medication has unique side effects.
These are not all of the side effects that may occur. Possessing potent antineoplastic properties, etoposide binds to and inhibits topoisomerase ii and its function in ligating cleaved dna molecules, resulting in the accumulation of single or doublestrand dna breaks, the inhibition of dna replication and transcription. Call your doctor if you have any unusual problems while taking this medication. Some side effects of etoposide may occur that usually do not need medical attention. Know etoposide uses, side effects, composition, substitutes, drug interactions, precautions, dosage, warnings only on. Etoposide solution for injection is to be administered slowly at a dosage of 50100 mgm 2 on days 1 to 5 every 3 or 4 weeks or 100 mgm 2 on days 1, 3 and 5 every 3 or 4 weeks. Etoposide is a widely used drug for chemotherapy that induces dna damage by inhibition of topoisomerase ii. Your cancer doctor or nurse can explain the risk of these side effects to you. There is a lot of evidence of its effectiveness and experience with what side effects you might have with this medication. Possible side effects of cisplatin, etoposide table version date. Tap along the timeline to move to different parts of the audio file.
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